2019年1月14日月曜日

How to prevent pneumonia fast !

WHAT IS PNEUMONIA ?

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Pneumonia is an inflammatory condition of the lung affecting primarily the small air sacs known as alveoli. Typically symptoms include some combination of productive or dry cough, chest pain, trouble breathing and fever. Severity is variable. 

Pneumonia is usually caused by infection with viruses or bacteria and commonly by other microorganisms, certain medications and conditions such as autoimmune diseases. Risk factors include other diseases such as cystic fibrosis, COPD, and asthma, diabetes, heart failure, environment cause and typically a history of smoking.


WHAT ARE THE SYMPTOMS OF PNEUMONIA ?

Pneumonia symptoms can be mild to life-threatening. The most common symptoms of pneumonia can include:


  1. Chest Pain
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  1. Fever, Sweating and Chills
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  1. Coughing That May Produce Phlegm (Mucus)
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  1. Shortness of Breath
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Other symptoms can vary according to the cause and severity of the infection, as well as the age and general health of the individual.



 SYMPTOMS BY CAUSE OF PNEUMONIA ?


  • Viral Pneumonia may start with flu-like symptoms, such as wheezing. A high fever may occur after 12 - 36 hours.
  • Bacterial Pneumonia may cause a fever as high as 105 F along with profuse sweating, nails, bluish lips and confusion.


SYMPTOMS BY AGE ?


  • Children under 5 years of age may have fast breathing
  • Infants may vomit, lack energy, or have trouble drinking or eating.
  • Older people may have a lower-than-normal body temperature.

WHAT ARE THE TYPE AND CAUSES OF PNEUMONIA ?

The major types of pneumonia are classified by the cause of the infection, where the infection was transmitted, and how the infection was acquired.

TYPES BY GERM

Pheumonia can be classified according to the organism that caused the infection.


  1. BACTERIAL PNEUMONIA: The most common cause of bacterial pneumonia is Streptococcus pneumoniae. Chlamydophila pneumonia and Legionella pneumophila can also cause bacterial pneumonia.
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  1. VIRAL PNEUMONIA: Respiratory viruses are often the cause of pneumonia, especially in young children and older people. Viral pneumonia is usually not serious and lasts for a shorter time than bacterial penumonia.
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  1. MYCOPLASMA PNEUMONIA: Mycoplasma organisms are not viruses or bacteria, but they have traits common to both. Mycoplasmas generally cause mild cases of pneumonia, most often in older children and young adults.
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  1. FUNGAL PNEUMONIA: Fungi from soil or bird droppings can cause pneumonia in people who inhale large amounts of the organisms. They can also cause pneumonia in people with chronic diseases or weakened immune systems.
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IS PNEUMONIA CONTAGIOUS?

Most types of bacterial pneumonia are not highly contagious. Even though it is possible to spread bacteria from one person to another, pneumonia typically occurs in people with risk factors or weakened immune defenses when bacteria that are normally present in the nose or throat invade the lung tissue. Any kind of bacterial or viral pneumonia has the potential to be contagious, but Mycoplasma pneumoniae and Mycobacterium tuberculosis (the cause of tuberculosis) are two types of bacterial pneumonia that are highly contagious. Breathing in infected droplets that come from patients who are coughing or sneezing can spread the disease to others.


WHAT IS THE CONTAGIOUS PERIOD FOR PNEUMONIA? 

It is impossible to say with certainly exactly how long an adult or child with pneumonia is contagious, since this varies according to they type of germ or organism that caused the pneumonia. This contagious period can ranged from one to two days to weeks. In general, while an infected person is coughing or sneezing, there is the potential to release contaminated droplets into the air.

Many bacterial pneumonias are much less contagious after antibiotics have been taken for about 24-48 hours. However, this time period may vary for some organisms. For example, with tuberculosis, it can take two weeks or more of antibiotics before the person is no longer contagious after the symptoms have improved, especially fever. Some people with viral pneumonia may not be contagious after one to two days with no fever, but others may still shed some infectious virus particles for a much longer time.


WHAT ARE RISK FACTORS FOR PNEUMONIA ?

There are a number of factors that increase the risk of developing pneumonia. These include 

  • Infant and children 2 years of age or younger;
  • age 65 and older;
  • a weakened immune system, either due to disease such as HID/AIDS or cancer, or to medications that suppress immune function;
  • having a chronic disease such as pulmonary disease (including cystic fibrosis and COPD), sickle cell anemia, asthma, heart disease or diabetes;
  • malnutrition;
  • swallowing or coughing problems, as may occur following stroke or other brain injury;
  • cigarette smoking;
  • being a patient in an intensive care unit of a hospital, particularly if on ventilator support.


WHAT IS THE TREATMENT FOR PNEUMONIA ?

Antibiotic medications are the treatment of choice for pneumonia caused by bacterial and fungal infections. The exact choice of medications depends on many factors, including the following:


  • The patient's underlying health condition
  • The organism responsible for the infection
  • The likelihood that the organism is resistant to certain antibiotics

IS IT POSSIBLE TO PREVENT PNEUMONIA ? IS THERE A PNEUMONIA VACCINE ?

It is not possible to prevent all types of pneumonia, but one can take steps to reduce the chance of contracting the condition by quitting smoking, practicing good hand-washing, and avoiding contact with people who have colds, the flue, or other infections.

A vaccine is available against the most common bacterial cause of pneumonia, Streptococcus penumoniae (also known as Pneumococcus). There are two types of vaccine: PPSV23 (Penumovax), a penumococcal polysaccharide vaccine against 23 types of the bacteria, and PCV13 (Prevnar 13), a penumococcal conjugate vaccine that protects against 13 types of bacteria. These vaccines may not always prevent penumococcal penumonia, but they may prevent serious complications of pneumonia if it does occur.

Avoidance of areas where fungal pathogens are endemic is recommended to prevent fungal pneumonias. There is no antifungal vaccine available: however, for some high-risk patients, some doctors have recommended prophylactic antifungal drugs.




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@ Jackie San

2019年1月10日木曜日

To the cure wellness, gadgets and life style

A - The Cure
(Inspiring Health and Wellness)

1-Bold Colours
Make a bold statement this holiday season with Bobbi Brown's Luxe Lip Colour -  now put together in a collection of ten scaled-down tubes in the Luxe on Luxe Mini Lip Colour Collection. This versatile and portable lipstick wardrobe fits into the smallest evening clutch and uses a formula that delivers full coverage while boosting moisture levels to keep lips soft and smooth throughout the evening. 

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2-Organic Best-Sellers
Go organic this holiday season with the best natural body care products Melvita has to offer in its All Time Favourite Gift Set. Repair and strengthen dry and damaged skin with the remarkable skincare properties of Organic Argan Oil or moisturise and refresh with Melvita's best-selling Organic Rose Floral Water, Cleanse, tone or nourish-this gift bag has a little something for all skincare needs.

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3-Perfect Complexion
The Korean secret to perfect skin is now within reach with the Erborian Perfect Skin for a Perfect Day! Gift Set. Outshine the fairest weather with Erborian's famous CC Cream (Dore'), formulated to protect and hydrate while leaving your complexion radiant and flawless with minimal effort. Use the multipurpose Matte Cream to even out skin tone and blur out imperfections while giving the face a natural-looking powdery finish.

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4-Rejuvenating Glow
Wake up to revived skin every day with the Sothys Rejuvenate Coffret Set. This little Christmas care package comes with two of the brand's most wanted items: Detox Resurfacing Overnight Cream and Energising Booster Serum. The combination is designed to work on the face through the night, detoxifying, nourishing and rejuvenating tired skin to restore a healthy glow the next morning. 

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B - Our pick of gadgets to have
(Gadgets and Gizmos)

1-Pure Android Performance
The new Nokia 6.1 Plus and 5.1 Plus are designed with an improved user experience in mind. Both smartphones (each with its own set of appealing features and specs) are part of the Android One programme, which offers three years of monthly security patches and two years of guaranteed OS updates after launch. 

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2-Peace and Quiet
The WH-1000XM3 is Sony's latest noise-cancelling headphones. This headband-style around-ear model features a newly developed HD noise-cancelling processor that not only negates transport noise but also tunes out daily background sounds like street noise and human voices.

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3-Always Safe
Otterbox has unveiled an attractive lineup of cases for the iPhone XS, XS Max and XR. While the varying designs range from trendy and slim to rugged and burly, plus everything in between, they similarly promise uncompromising protection against drops, bumps, scratches and dings.

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4-Cashless Convenience
Boost is Malaysia's one-stop e-wallet, allowing a person to order food, top up prepaid, pay phone bills and more just by using a phone. Travellers can even scan and pay at Malaysian airports and shake to get cashback, plus buy KLIA Express tickets at 10 percent off -  all at the convenience of one tap.

 
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C - Fashion and Accessories
(Gift Guide)

1-Forever Young
To mark Mickey Mouse's 90th Birthday, Pandora has released a very special charm. It is crafted from the jewellery brand's signature sterling silver and depicts the famous cartoon character in a playful pose. The digits of the number 90 are crafted from 14k gold, marking the milestone anniversary.

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2-Flying Around The Clock
The Oris Big Crown ProPilot Calibre 114 is a tribute to aviation and the watchmaker's love for innovation. It is powered by a new movement that combines a 10-day power reserve, patented non-linear gauge, date indication and -  for the first time - a 24 hour second time zone with half-hour markings.

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3-Made For Hard Knocks
Leather Avenue's polycarbonate Mendoza Mar-X luggage case seeks to inspire intrepid adventures. Daring and non-conformist, it embodies the endless possibilities of travel. It rocks three original design factors: an innovative 3D form, smart mobility features and creative structures. 

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4-In Good Time
Frederique Constant is celebrating 30 years of watchmaking know-how with a limited edition timepiece. The Perfectual Calendar Tourbillon Manufacture features a new movement, featuring a silicium escapement wheel and anchor and 38 hours of power reserve while running at 4 Hz. 

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5-Timeless Edge
Created in the 1970s, Cartier's Juste Un Clou unisex bracelet is an iconic design that has withstood time. It has long been embraced as an object of everlasting style. A new version, which is available in yellow and pink gold, embodies an assertive attitude and can be worn alone or alongside the original. 

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6-Fashion Flashback
Coach is taking a walk down memory lane for its 2019 Pre-Spring collection. More specifically, the rock 'n' roll and punk culture of the yesteryears. The label's fringe saddle bag in shiny red leather, for one, ticks all the right boxes when it comes to paying tribute to music and an authentic retro style. 


7-An Exquisite Bloom
With elegant stone inlays of carnelian and lapis lazuli, the De Beers Enchanted Lotus Pendant is indeed magical to behold. Created to adapt to the lifestyle of the modern woman, it can also be won in reverse, revealing a discreet round brilliant diamond for a simple and sophisticated look.

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8-Return Of The Bond Watch
Omega's new Seamaster Diver 300M is a watch that can take you from a formal occasion to the depths of the ocean without missing a beat. This new 42mm model includes an updated ceramic bezel, as well as a ceramic dial laser-engraved with a wave pattern - and is water resistant up to 300m.

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Other article you can find and read in this blog.
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@ Jackie San

2018年12月27日木曜日

Human Genetics and Genetic Diseases

HIGHLIGHTS OF LATEST ADVANCES ON HUMAN GENETICS MEET 2019

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Track 01 # : HUMAN GENETICS

Human Genetics is the branch of genetics which involves the study of inheritance that occurs in humans. It includes various subfields such as classical genetics, cytogenetics, molecular genetics, biochemical genetics, genomics, population genetics, development genetics, clinical genetics, and genetic counseling. Study on human genetics, can explain the human nature, understand and development of effective treatment for diseases.

  • Genomics
  • Genetic Differences and Inheritance Patterns
  • Population Genetics
  • Evolutionary Genetics
  • Mitochondrial DNA
  • Genomics


Track 02 # :  GENETICS DISEASES

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Genetic Disorder may be caused as a result of new mutation or changes that occur in DNA. It is also a hereditary disease that is caused by parent gene. Mostly it caused due to the abnormalities in the genome. Genetic disorders are classified into different types depending upon single gene or multiple genes. Around 4000 disease are categorized as single gene defect. Some of the multifactorial disorders include heart diseases and diabetes. Some of the common diseases are asthma, Diabetes, Hypertension, and Obesity.

  • Diagnosis of the Genetic Disorder
  • Gene Therapy
  • Inborn Errors of Metabolism
  • Prognosis of the Genetic Disorder

Some of the Common Genetic Disorder:
  • Breast Cancer
  • ADA Immune Deficiency
  • Cystic Fibrosis
  • Down Syndrome
  • Alzheimer Disease
  • Duchenne Muscular Dystrophy
  • Ectrodacytly
  • Fragile X Syndrome
  • Hemophilia
  • Hunter Syndrome
  • Jackson-Weiss Syndrome
  • Melanoma
  • Muscular Dystrophies
  • Retinoblastoma
  • Neurofibromatosis
  • Gaucher Disease
  • Retinoblastoma
  • Inherited Arrhythmia Disorders
  • Severe Combined Immunodeficiency Disorder (SCID)
  • Werner Syndrome
  • Lysosomal Storage Disease
  • Sickle Cell Anaemia
  • Tay-Sachs
  • Thalassemia
  • Tunner Syndrome



Track 03 # : GENOMICS

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Genomics is the field of genetics which deals with the study of structure, function, evolution, mapping, and editing of genomes. Genomics involves the sequencing and analysis of genomes using DNA sequencing and bioinformatics to assemble and analyze the function and structure of entire genomes.

Advancement in genomics made a transformation in discovery-based research and systems biology to understand complex biological systems such as the brain.

  • Functional Genomics
  • Epigenomics
  • Metagenomics
  • Applications of Genomics -  Genomic medicine, Conservation Genomics
  • Structural Genomics


Track 04 # : SICKLE CELL ANAEMIA

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Sickle-cell disease (SCD) is a group of blood disorders typically inherited from an individual's parents. Amongst all, the most type is known as sickle-cell anaemia (SCA). An abnormality in the oxygen-carrying protein haemoglobin (haemoglobin S) found in red blood cells is seen in SCD. This mainly leads to a rigid, sickle-like shape under certain circumstances. Sickle cell disease Problems typically begin around 5 to 6 months of age. Sickle-cell disease caused due to when inheritance two abnormal copies of the haemoglobin gene, one from each parent. This gene present in chromosome 11. Various subtypes exist, depending on the exact mutation in each haemoglobin gene. An attack can get started with temperature changes, stress, dehydration, and high altitude.

  • Genetics of Sickle Cell Anaemia
  • Signs and Symptoms
  • Pathophysiology of Sickle-Cell Disease
  • Diagnosis of Sickel Cell Diseases



Track 05 # : THALASSEMIA

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Thalassemia is characterized as an abnormal hemoglobin producing condition. It is a type of inherited blood disorders. Symptoms are mild to severe anemia due to low red blood cells count. Anemia can make one feel tired and have pale skin. Bone problems, an enlarged spleen, yellowish skin, dark urine, among children slow growth are other related symptoms or Thalassemia.

There are two main types in Thalassemia, alpha Thalassemia, and Beta Thalassemia. Diagnosis is done by blood tests including a complete blood count, special haemoglobin tests, and genetic tests. Diagnosis can also be done before birth by prenatal testing.

  • Prevention
  • Management of Thalassemia
  • Signs and Symptoms
  • Pathophysiology


Track 06 # : MEDICAL GENETICS

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Medical Genetics is a branch of medicine that involve diagnosis and management of genetic disorders. Slightly medical genetics and human genetics differ in certain ways, where human genetics is a field of scientific research which may or may not apply to medicine but medical genetics depend on the applications of genetics to medical care.

  • Genetic Medicine - Gene Theraphy, Personalized Medicine and Predictive Medicine
  • Genetic Counselling
  • Subspecialities -  Clinical genetics, Metabolic/Biochemical genetics, Cytogenetics, Molecular Genetics, Mitochondrial Genetics
  • Diagnostic Evaluation - Chromosome Studies, Basic Metabolic Studies, Molecular Studies


Track 07 # : HUMAN EVOLUTIONARY GENETICS

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Human evolutionary genetics explain how one human genome will differ from another human genome, from where the evolutionary past arrived that gave rise to it, and also its the current effects. This disparity between the genomes has anthropologival, historical, medical and forensic implication and applications. Genetic data can provide important insight into human evolution. It helps one to understand the differences in the human genome and learn about how evolution has affected the development of the genome and acquired diversity. 

  • FOXP2 and Human Evolution
  • Genetic Genealogy
  • Archaegenetics
  • Human Genetic Variation
  • Race and Genetics



Track 08 # : GENOME EDITING

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It is a type of genetic engineering which involves addition, deletion, and insertion or modification of genome in an organism. The common thing in this research is to modify DNA sequence and observe the changes on the organism. This method is known as reverse genetics where it is vice versa to forward genetics in which the phenotype will be observed first and genetics of the organism will be studied later.

  • Gene Therapy
  • Site-Directed Mutagenesis
  • Role of CRISPR in Genome Editing
  • Eradicating Diseases



Track 09 # : CANCER GENETICS

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Cancer genetics studies about the heritable gene variants in humans and other animals that causes the change in risk of tumour or haematological malignancy. An Individual cancer risk varies and is influenced by familial and sporadic oncogene or tumour suppressor gene mutations as well as rare and common constitutional variants present in the population. For many years, cancer genetics has mainly focused on mutational events which hae their own primary effect within the cancer cell.

  • Molecular Diagnostics for Cancer
  • Next Generation Sequencing in Cancer
  • Cancer Pharmacogenetics
  • Cancer Epigenetics
  • Cancer Genome Sequencing
  • Cancer Genomics


Track 10 # : EPIGENETICS

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Epigenetics is a biological mechanism exhibiting functionally relevant changes to the genome that does not involve changes in the DNA sequences. Epigenetics controls the gene expression through the action of repressor protein that attaches to silencer regions of the DNA, switching between turn on and off of a gene, leading to alteration in the chromosomal regions.

  • Epigenetic Modifications in Cardiovascular Disease
  • Epigenetic Therapy
  • Epigenetics of Neourodegenerative Diseases
  • Nutriepigenomics
  • Behavioral Epigenetics
  • Computational Epigenetics



Track 11 # : BIOINFORMATICS AND COMPUTATIONAL BIOLOGY

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Bioinformatics is an interdisciplinary subject that develops methods and software tools for the understanding concept of biological data. As an interdisciplinary field of science, bioinformatics is a combination of biology, computer science, mathematics and statistics to analyze and interpret the biological data. Using mathematical and statistical techniques, in silico analyses of biological queries is carried out in Bioinformatics.

  • Cancer Computational Biology
  • Comparative Genomics
  • Novel Bioinformatics/Computational Tools and Methods
  • Computational Epigenetics
  • Computational Evolutionary Biology
  • Computational Phylogenetics
  • Comparative Genomics



Track 12 # : DNA SEQUENCING

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DNA sequencing is the process of determining the actual order of nucleotide (Adenine, Guanine, Cytosine, and thymine) within a DNA molecule. THis technique is used in various fields such as medical diagnosis, biotechnology, forensic biology, virology, and biological systematics and anthropology.

  • Basic methods - Maxam - Gilbert Sequencing, Chain-Termination Methods
  • Advanced Methods and De Novo Sequencing -
  1. Bridge PCR
  2. Shotgun Sequencing
  • High - Throughput Methods -
  1. Massively Parallel Signature Sequencing (MPSS)
  2. Polony Sequencing
  3. 454 Pyrosequencing
  4. Ilumina (Solexa) Sequencing
  5. Solid Sequencing
  6. Ion Torrent Semiconductor Sequencing, DNA Nanoball Sequencing
  7. Heliscope Single Molecule Sequencing
  8. Single Molecule Real Time (SMRT) Sequencing
  9. Nanopore DNA Sequencing
  • Methods in Development-
  1. Tunnelling Currents DNA Sequencing
  2. Sequencing by Hybridization
  3. Microfluidic Sanger Sequencing
  4. RNAP Sequencing
  5. In Vitro Virus High-Throughput Sequencing
  • Cancer Genome Sequencing
  1. Microscopy-Based Techniques
  2. Sequencing with Mass Spectrometry



Track 13 # : IMMUNOGENETICS

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Immunogenetics is under a division of medical genetics that exploits the relationship between the genetics and the immune system. Type 1 diabetes is an Autoimmune disease, it has complex genetic traits which result due to defects in the immune system. New target genes for therapeutic approaches are identified by identification of genes defining the immune defects. Alternatively, by making use of genetic variation the immunological pathway leading to disease is defined. It highlights the emerging technical and various conceptual breakthrough that pitch for mechanisms of anti-donor responses.

  • The immunogenetics of Neurological Disease
  • Bone Involvement in Monogenic Autoinflammatory Syndromes
  • Immune-Suppressive Effects of Interleukin-6
  • Mechanisms behind TB, HBV, and HIV Chronic Infections
  • Immunoglobulin Genotypes and Cognitive Functions



Track 14 # : PHARMACOGENOMICS AND PHARMACOGENETICS

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Pharmacogenomics is the study dealing with the response of an individual with respect to their genome to the administered drugs. As the name suggests it is the combination of two different fields that is pharmacology and genomics. Pharmacogenomics is often used interchangeably with pharmacogenetics. Adverse drug reactions are a significant cause of hospitalizations and deaths in many countries.

  • Chemogenomics
  • Personalized Medicine
  • Toxicogenomics
  • Clinical Pharmacogenetics
  • Pharmacogenetics in Cardiovascular Medicine



Track 15 # : GENE MUTATION

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A gene mutation happens due to permanent alteration in the DNA sequence that makes up a gene, in a way that the sequence differs from what is found in most of the normal individual. Mutations range in size, they can affect anywhere from a single DNA base pair to a large segment of a chromosome, one including multiple genes. It can be classified in two major ways that is hereditary mutations and acquired mutations.

  • Induced Mutations
  • Next generation Panel Sequencing
  • Site-Directed Mutagenesis
  • Autoinflammatory Disease Genes in Gene Mutation



Track 16 # : BEHAVIOURAL GENETICS

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Behavioural genetics is the branch of genetics which deals with the study of behaviour of an organism. It also differentiates behaviour of different organism depending upon the genetics. Behavioural genetic studies have extensively impacted cutting-edge know-how the role of genetic and environmental impacts on behaviour. Different methodology involved are Animal studies, Twin and family studies, Quasi-experimental designs.

  • Quantitative Genetics
  • Evolutionary Psychology
  • Genes, Brain and Behaviour
  • Human Behaviour Genetics
  • Psychiatric Genetics



Track 17 # : STEM CELL THERAPY

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Use of Stem cells for the treatment and prevention of diseased condition is categorized under stem cell therapy. Bone marrow transplant is found to be most widely used among various stem-cell therapies. Some stem cell therapies were acquired by using umbilical cord blood. Stem-cell therapy has turned into a controversial trailing to the developments where scientists are able to isolate and culture embryonic stem cells, to create stem cells using somatic cell nuclear transfer and their use of techniques to create induced pluripotent stem cells. These controversies often comprehend abortion politics and to human cloning. Stem cell therapy has been exploited for treatments of neuorodegenerative diseases and conditions such as diabetes and heart disease.

  • Role of Stem Cells in Cancer
  • Drug Discovery and Biomedical Research
  • Hematopoietic Stem Cell Transplantation
  • Regenerative Treatment Models



Track 18 # : NEUROGENETICS

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Neurogenetics is the branch of genetics which studies the development and function of nervous system. Many neurological disorders like Alzheimer's and Parkinson's diseases can be related to neurogenetics and the research of genetics on neurological disorder are still on going.

  • Current Research
  • Gene Sequencing
  • Neurological Disorders- Alzheimer's Disease and Parkinson's Disease
  • Methods of Research
  • Behavioral Neurogenetics



Track 19 # :  GENETIC COUNSELING

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Genetic counseling is the technique by which the patients or family liable to an inherited disease are counselled of the results and nature of the sickness, the possibility of growing or transmitting it, and the options open to them in management and family planning. This complicated procedure may be separated into diagnostic (the real estimation of threat) and supportive factors.

  • Reprogenetics
  • Genomic Counceling
  • Whole Genome Sequencing
  • Genetic Counsellors



Track 20 # : NUTRIGENOMICS

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Nutrigenomics is a department of nutritional genomics and is the study of the consequences of ingredients and food parts on gene expression. It is a area or research focusing on figuring out and knowledge molecular-level interaction between vitamins and different nutritional bioactives with the genome.

  • Anti-Aging
  • Public Health Genomics
  • Background and Preventive Health



Track 21 # : REGENERATIVE MEDICINE

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Regenerative medication is the department of translational studies which involves the method of replacing, engineering or regenerating human cells, tissues or organs to restore or set up regular function. This area holds the promise of engineering broken tissues and organs via stimulating the frame's very own restore mechanisms to functionally heal formerly irreparable tissues or organs

  • Biomedicine
  • Regeneration in Humans
  • Anti-Aging medicine
  • Stem Cell Treatments



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